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Narcotic analgesic combinations are potentially addictive and the risk of becoming emotionally and physically dependent on them increases the more you take and the longer you take them for. Ml Rational Opioid use. American Society of Addiction Medicine. Drewes AM, Jensen RD, Nielsen LM,. An Overview of Opioids, Pharmacy Times. What are the side effects of combination narcotic analgesics? See narcotic analgesics for an explanation of the different types of narcotics (opioids) that are available. Prostaglandins promote inflammation, pain and fever. The main opioid receptor that narcotic analgesics bind to is the mu receptor.

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